Join us for the first day of the hybrid meeting via Zoom live stream from the venue in Strasbourg.

10 talks – Q&A – poster session onsite

Access to live stream only for registered participants.

Online viewers, please stay muted and use the Zoom chat during discussions.

Wednesday, October 25, 2023

(all times are in CET)

Session 1 : Structural Approaches and Novel Technologies
Chair: Didier Rognan & Teodora Dikic-Stojsic

14:15 – Opening
14:30 – Valérie Panneels  – Laboratory for Biomolecular Research, Paul Scherrer Institute, Villigen, Switzerland.
First molecular events of vision, structure of ultrafast rhodopsin in movement captured with an X-ray free electron laser”
15:20 – Frank Bernhard – Goethe University Frankfurt, Germany.
“Cryo-EM structures of cell-free synthesized human GPCR/G protein complexes in lipid environment”
15:45 – Hélène Déméné  –  CBS, CNRS-INSERM, University Montpellier, France.
“Activation of the vasopressin V2 receptor seen by an integrative approach”
16:10 – Jenny Filor  –  University Hospital Jena, Germany.
“Muscarinic acetylcholine receptors M2 and M4: interaction with β-arrestin and internalization to endosomes”
16:25 – Lauri Urvas and Luca Chiesa – Illkirch, France.
“Benchmarking AlphaFold-generated structures of chemokine – chemokine receptor complexes”
16:40 – Pauline Scholler – Revvity, France.
“New insights into GPCR functions and signaling by combining Revvity cell-based assays”

16:55 – Coffee break at the venue

17:30 – Claire de March  – Institut de Chimie des Substances Naturelles, UPR2301 CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
“Structural basis of odorant recognition”
18:20 – Christoph Klenk – University of Zurich, Switzerland.
 “Tuning GPCR expression, stability and allostery by directed evolution in mammalian cells”
18:45 – Alexei Sirbu  –  Max Delbrück Center for Molecular Medicine, Berlin, Germany.
“Functional modulation of ß2AR by cortical actin cytoskeleton”
19:00 – Pauline Raynaud  –  INRAE, Nouzilly, France.
“Single domain intrabodies specifically targeting the follicle-stimulating hormone receptor (FSHR) affect receptor signalling and trafficking”

19:15 – Poster session & buffet (onsite only)

View online posters in the virtual POSTER HALL.

On the second day, we will live-stream 5 talks and industrial presentations in Session 2: GPCRs, Signalling & Trafficking and continue after a break with 8 talks in Session 3: GPCRs and Physiology.

Online viewers, please stay muted and use the Zoom chat during discussions.

Thursday, October 26, 2023

(all times are in CET)

Session 2 : GPCRs, Signalling & Trafficking
Chairs: Dominique Massotte & Renaud Wagner

9:00 – David J. Hodson  – Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, UK.
Understanding GLP-1 and GIP receptor expression and signalling in the brain and periphery
9:50 – Olivier Lahuna – INSERM, Paris, France.
“Intrication of the melatonergic pathway and the endocannabinoid system (ECS) through the Melatonin / Cannabinoid Type 1 Receptors (MT1/CB1) Heteromers“

10:15 – Coffee break at the venue

10:45 – Martha Sommer – ISAR Bioscience Institute, Munich-Planegg, Germany. 
The arrestins: evolutionary ‘old dogs’ performing complex tricks in GPCR/7TMR signal transduction
11:35 – Cornelius Krasel – Institute of Pharmacology and Clinical Pharmacy, University of Marburg, Germany.
“Mutations of lysines to arginines in the N-terminus of arrestins impairs arrestin binding to GPCRs by attenuating the release of the arrestin C-terminus”
12:00 – Junke Liu – Institut de Génomique Fonctionnelle, Montpellier, France.
“Distinct roles of β-arrestins in GPCR endocytosis”

12:30 – Photo & lunch at the venue

Session 3 : GPCRs and Physiology
Chairs: Claire Gavériaux-Ruff & Michel Barrot

14:30 – Simon M. Luckman – Faculty of Biology, Medicine and Health, University of Manchester, UK.
“PrRP-GPR10 signalling in metabolism”
15:20 – Sandra Lecat  – CNRS / University of Strasbourg, France.
“GPRASP1 is critical for airway hyperresponsiveness and tolerance following chronic beta2-adrenoceptors stimulation”
15:45 – Hélène Castel  –  University of Rouen Normandie, France.
“The urotensin II receptor instructs meningeal inflammation and macrophage-induced vasospasm during brain hemorrhagic stroke”
16:10 – Mona Reichel  – University Hospital Jena, Germany.
“The distinct roles of the GRK isoforms for the Endothelin-1 A receptor (ETAR) in ovarian cancer”

16:25 – Coffee break at the venue

17:00 – Cyril Rivat   University Montpellier / INSERM U-1298, Institut des Neurosciences de Montpellier, France.
FLT3 signaling in opioid side effects”
17:50 – Véronique Pons – INSERM, Toulouse, France.
“Platelet P2Y1 receptor exhibits constitutive activity on both G protein signaling and b-arrestin 2 recruitment”
18:15 – Célia R. S. Garcia – University of São Paulo, Brasil.
“Decoding the role and signal transduction mechanism of GPCR-like proteins in malarial parasites”
18:40 – Julie Sanchez  –  University of Nottingham, UK.
“TRPing receptors – modulatory effect of TRP channels on GPCRs”

18:55 – General assembly (onsite only)

19:15 – Poster session & buffet (onsite only)

View online posters in the virtual POSTER HALL.

On the last day of the meeting, you can follow 6 talks in Session 4: Novel Ligands / Drug Development being live -streamed from the venue. The event will conclude with a final discussion and an award ceremony for talks and posters.

Friday, October 27, 2023

(all times are in CET)

Session 4 : Novel Ligands / Drug Development
Chairs: Dominique Bonnet & Frédéric Bihel

9:00 – Matthias Schiedel  – Department of Chemistry and Pharmacy
Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.
“Targeting from the inside – New approaches for GPCR-based drug discovery”
9:50 – Dmitry B. Veprintsev – University of Nottingham, UK.
“Ligand-Directed Covalent Probes to study Cannabinoid Receptor 2 in Live Cells”
10:15 – Xavier Gómez-Santacana  – Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.
“A toolbox of photo switchable allosteric modulators to control the activity of metabotropic glutamate receptors with light”

10:30 – Coffee break at the venue

11:00 – Philippe Rondard – University of Montpellier – CNRS – INSERM, Montpellier, France.
“Single domain antibodies targeting GPCRs as novel therapeutic agents for brain diseases“
11:25 – Floriane Eshak  –  University Paris Cité, Paris, France.
“Epitope identification using in-silico approaches, a case study : nanobodies binding to mGlu5 receptor”
11:40 – Jens Carlsson  –  Department of Cell and Molecular Biology, Uppsala University, Sweden.
“Structure-based discovery of GPCR ligands with tailored pharmacological properties

12:30 – Awards & conclusions
12:45 – End of the meeting

Join Live Stream

Get online access to the 3rd i-GPCRnet annual meeting. Only registered participants can join the Zoom live stream via passcode. Please contact us if you have not received your passcode by email.

Virtual Poster Hall

View virtual posters on recent GPCR research in the virtual poster hall. Access via passcode sent by email to all registered participants.


Watch recorded talks of the meeting. Recordings will be uploaded at the end of each event day and are available until Nov 24, 2023. Access via passcode sent by email to all registered participants.

i-GPCRnet Website

Go to the i-GPCRnet meeting website for additional information on how to register online and contact the organizers for this event.